Progynova is a medication that contains estradiol valerate, a synthetic form of the female hormone estrogen. It is commonly used as hormone replacement therapy in postmenopausal women to relieve symptoms such as hot flashes, vaginal dryness, and mood changes. It can also be used in transgender hormone therapy to help feminize the body.

Progynova is typically taken orally once a day, with or without food. The dosage and duration of treatment will depend on the individual's condition and medical history. Common side effects include headache, nausea, breast tenderness, and bloating. Rare but serious side effects may include blood clots, stroke, and breast or uterine cancer.