Asthma is considered as a chronic inflammatory disorder of the airways which is involved with a complex interaction of airflow obstruction, underlying inflammation, and bronchial hyperresponsiveness. Asthma exacerbations are exaggerated lower airway response to the environmental exposure. The inflammation mechanism is asthma may be subacute, acute, or chronic, and the presence of mucus secretion and airway edema may contribute to bronchial reactivity and airway obstruction. The presence of bronchial hyperactivity and airway hyperresponsiveness in asthma is exaggerated response to the numerous endogenous and exogenous stimuli (Tunnicliffe, & Stanley, 2008).