QuickBooks error 61 is usually caused by malfunctioning hardware or corrupted file and when the software experiences issues with Windows registry or . NET framework. In addition to a damaged or corrupted QuickBooks company file, there can be numerous reasons which can cause this QuickBooks Desktop error code 61 on your system. Using tools like the Re-image Repair Tool and by installing the updates, you can expect this problem to stop appearing while you use the QuickBooks software.