Guntur Kaaram is an action romance starring Mahesh Babu as the protagonist - Karam, the notoriously powerful kingpin of Guntur's shadowy underworld operations. Though feared by law enforcement and criminals alike, Karam has carefully cultivated public persona as a respectable businessman and philanthropist.

Karam's unlawful empire controlling Guntur thrives through extortion rackets and influence peddling that keeps corrupt public officials silent. However, Karam finds an unlikely challenger in the form of Satya, an intrepid investigative journalist. She arrives in Guntur determined to expose the rampant crime, government collusion and Karam's links to every shady deal brokering the illegal schemes running the city from behind a façade.