How to use USB drives in a safe and secure manner?

When people were struggling with low space compact disks and floppy disks, the USB drive came into the cyber world as a long required relief. It made transferring and storing of data way easier. But as always as these tiny devices are, they can also be a potential carrier of malware, and thus a favourite place for hackers. Let us check how USB devices, also known as flash devices, can be a big safety threat.