The most serious type of cardiovascular calcification in dialysis patients is called calciphylaxis, also known as calcific uremic arteriolopathy (CUA). Small peripheral vessels begin to calcify at the beginning, and it quickly spreads throughout the body. In addition, those who have calciphylaxis have an imbalance in their calcium metabolism, which results in calcium being deposited in their arterioles, which finally causes blood clots to form in the arterioles. Blood clots may deprive skin and fat areas of oxygen and nutrition.